Question:
WHat is diabetes? (Type 1)? What is insulin? what are the causes of
getting diabetes? How can someone get better? treatments for diabetic?
Answer:
The basic answer to your question:
Type 1 diabetes is a disease marked by the autoimmune destruction of the
beta cells in your pancreas. No beta cells means no insulin. No insulin
means you can't metabolize carbohydrate and you die rather quickly unless
you start injecting insulin
The basic cause is genetics. You have the wrong genes; something sets
off your immune system; you form antibodies which kill your beta cells and
voila, you have diabetes.
You don't ever get better unless you can figure out how to get a new
pancreas or new beta cells. Current therapy calls for injecting several
shots of insulin each day. I inject 7 times a day unless it's a difficult
day which forces me to inject more often.
A better answer to your question:
Actually, the answers to your questions are worth a book. Here's one
already written, then put on a web site. Pick out the topics you are
interested and have at it.
Endotext very superior overview of all aspects of T1 and T2
http://www.endotext.org/diabetes/index.htm
table of contents
INSULIN AND GLUCAGON PHYSIOLOGY
2. Insulin Signaling and Action: Glucose, Lipids, And Protein Bei Zhang, PhD
3. Insulin Biosynthesis, Secretion, Structure, And Structure-Activity
Relationships Isaiah Pittman IV, Louis H. Philipson, and Donald F. Steiner
4. Insulin Receptor Ronald Kohanski, PhD
5. Glucagon Physiology Niyaz R. Gosmanov, MD, Tamar S. Smith, and John E.
Gerich, MD
PATHOGENESIS OF DIABETES
7. Classification And Diagnosis Of Diabetes
Charles Reasner, MD, and Ralph A. DeFronzo, MD
8. Pathogenesis Of Type 1A Diabetes George Eisenbarth, MD
9. Pathogenesis Of Type 2 Diabetes Ralph A. DeFronzo, M.D., and Lawrence J.
Mandarino, Ph.D.
10. Non Type 1 - Non Type 2 Diabetes Mellitus Earle, KE, Rushakoff RJ, and
Goldfine ID
11. Hyperandrogenism, Hirsutism and Polycystic Ovary Syndrome Randall B.
Barnes, M.D., Adrienne B. Neithardt, M.D. and Suleena K. Kalra, M.D.
12. Glucose Toxicitsy George Fantus, MD
MODALITIES FOR TREATMENT OF DIABETES
13. Insulin - Pharmacology, Types of Regimens and Adjustments Lisa Kroon,
PharmD, CDE
14. Oral Pharmacological Agents for Type 2 Diabetes: Sulfonylureas,
Meglitinides, Metformin, Thiazolidinediones, a-Glucosidase Inhibitors, and
Emerging Approaches Joseph Evans, PhD and Robert Rushakoff, MD
15. Diet, Botanical, and Nutraceutical Treatments for Type 2 Diabetes Joseph
L. Evans, Ph.D.
16. Summary of Current Outcome with Pancreas or Islet Transplantation David
E.R. Sutherland, MD, Ph.D.
17. Islet Transplantation Breay W. Paty, MD, FRCPC
18. New Therapies- Inhaled Insulin, Oral Insulin, Others
DIABETES TREATMENT - STRATEGIES
20. Goals For Management
21. Monitoring Control- Home Monitoring, Hga1c, Non-Invasive Monitoring
David Klonoff, MD
22. Diabetes Disease Management: Integrating Diabetes Self-Management
Education Strategies and Diabetes Treatment Principles Anne Peters Harmel,
MD
23. Management Of Hospitalized Patients Robert Rushakoff, MD
24. Insulin Strategies in Management of Type 2 Diabetes Juliuo Rosenstock,
MD
25. Exercise and the Regulation of Blood Glucose Jack Youngren, PhD
26. Management of Diabetes in Pregnancy Linda A. Barbour, M.D., M.S.P.H.,
and Jacob E. Friedman, Ph.D.
27. Management of Diabetes in Children Svetlana Ten, MD and Noel Maclaren,
MD
28. Syndrome X Insulin Resistance, Hyperinsulinemia, and Coronary Heart
Disease Gerald Reaven, MD
DIABETIC COMPLICATIONS
30. Ketoacidosis And Hyperosmolar Coma Allen Arieff, MD
31. Hypoglycemia During Therapy of Diabetes Philip Cryer, MD
32. The Role of Lipids in Increasing Cardiovascular Diseases Ken Feingold,
MD
33. Retinopathy Jay M. Stewart, MD and Daniel Schwartz, MD
34. Diabetic Nephropathy Allen I. Arieff, M.D., F.A.C.P.
35. Neuropathy Aaron Vinik, MD
36. Hypertension in Diabetes Christopher J. Lyon, Ph.D., and Willa A. Hsueh,
M.D.
TUMOR SYNDROMES
39. Insulinoma and Other Hypoglycemias Alan Siperstein, MD, Orlo H. Clark,
MD, and Robert J. Rushakoff,MD
See also Insulinoma Roger Perry, MD
41. Current Strategies for the Prevention of Type 1 and Type 2 Diabetes
Mellitus Dennis G. Karounos, M.D.
